GeT-Biopuces

TBI platform for genomics and transcriptomics.
Sequencing and microarrays.

Technical Expertise

Certified ISO-9001 et NFX50-900

For academic and private research

From samples quality control to data analysis

taff with more than 15 years experience in the field

Innovation

Microbiology referee within the regional GeT platform

Development of diagnostic and custom chips

Project accomodation


Development

Collaboration

Non-disclosure agreements

Skill Transfert (Contact us) and
professional training sessions

About us

Created in 1999 and currently spearheaded by Marie-Ange Teste, the GeT-Biopuces core-facility is one of the first platform of the Génopôle Toulouse Midi Pyrénées (GenoToul).

Labellised IBISA and certifiée ISO 9001 since 2010, the GeT-Biopuces core-facility is dedicated in transcriptomics and genomics and offers service delivery and/or collaboration (R&D).

The Core Facilities and staff offer its expertise and advanced tools for sequencing, microarrays and analysis of bioinformatics and statistical data.

Thanks to the know-how of its multidisciplinary team, you are assisted along your project from its conception to the availability of raw or processed data.

Lots of academic (INRAE, CNRS, INSERM, IFREMER...) and private partners have trusted us to collaborate on fundamental or applied research projects in various fields such as microbiology, biotechnology, agri-food industry, health and the environment. Intellectual property issues and non-disclosure agreements can be discussed with the legal department of INSA.

The GeT-Biopuces platform is part of a cutting-edge multi-site core facility in Toulouse, named GeT for ‘Genome and Transcriptome’.

Thus we propose one of the most complete offers in France in the field of genomics and transcriptomics: DNA chips, small and long fragment high throughput sequencing technologies, ddPCR and single- cell

Services and Equipment

Why working with us ?

The platform offers the following services:

For any question, feel free to contact us, our staff will answer you a soon as possible.

Publications

2021

Piqueras, Justine, Christophe Chassard, Cécile Callon, Etienne Rifa, Sébastien Theil, Annick Lebecque, et Céline Delbès. « Lactic Starter Dose Shapes S. Aureus and STEC O26:H11 Growth, and Bacterial Community Patterns in Raw Milk Uncooked Pressed Cheeses ». Microorganisms 9, nᵒ 5 (mai 2021): 1081. doi:10.3390/microorganisms9051081.
Paccoud, Romain, Céline Saint-Laurent, Enzo Piccolo, Mylène Tajan, Alizée Dortignac, Ophélie Pereira, Sophie Le Gonidec, et al. « SHP2 Drives Inflammation-Triggered Insulin Resistance by Reshaping Tissue Macrophage Populations ». Science Translational Medicine 13, nᵒ 591 (28 avril 2021). doi:10.1126/scitranslmed.abe2587.
Millard, Pierre, Brice Enjalbert, Sandrine Uttenweiler-Joseph, Jean-Charles Portais, et Fabien Létisse. « Control and regulation of acetate overflow in Escherichia coli ». Édité par Michael Doebeli et Naama Barkai. eLife 10 (15 mars 2021): e63661. doi:10.7554/eLife.63661.
Arnould, Coline, Vincent Rocher, Anne-Laure Finoux, Thomas Clouaire, Kevin Li, Felix Zhou, Pierre Caron, et al. « Loop Extrusion as a Mechanism for Formation of DNA Damage Repair Foci ». Nature 590, nᵒ 7847 (février 2021): 660‑65. doi:10.1038/s41586-021-03193-z.
Courtot, Lilas, Elodie Bournique, Chrystelle Maric, Laure Guitton-Sert, Miguel Madrid-Mencía, Vera Pancaldi, Jean-Charles Cadoret, Jean-Sébastien Hoffmann, et Valérie Bergoglio. « Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing ». International Journal of Molecular Sciences 22, nᵒ 9 (janvier 2021): 4959. doi:10.3390/ijms22094959.

2020

Pavlovic, Marion, Christelle Gross, Chahinaize Chili, Thomas Secher, et Emmanuel Treiner. « MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands ». Frontiers in Immunology 11 (8 septembre 2020): 2097. doi:10.3389/fimmu.2020.02097.
Tauzin, Alexandra S., Mariana Rangel Pereira, Liisa D. Van Vliet, Pierre-Yves Colin, Elisabeth Laville, Jeremy Esque, Sandrine Laguerre, et al. « Investigating Host-Microbiome Interactions by Droplet Based Microfluidics ». Microbiome 8, nᵒ 1 (décembre 2020): 141. doi:10.1186/s40168-020-00911-z.
Bertorello, Juliette, Julie Sesen, Julia Gilhodes, Solène Evrard, Monique Courtade-Saïdi, Meera Augustus, Emmanuelle Uro-Coste, et al. « Translation Reprogramming by EIF3 Linked to Glioblastoma Resistance ». NAR Cancer 2, nᵒ 3 (1 septembre 2020): zcaa020. doi:10.1093/narcan/zcaa020.
De Simone, A., C. M. Vicente, C. Peiro, L. Gales, F. Bellvert, B. Enjalbert, et S. Heux. « Mixing and Matching Methylotrophic Enzymes to Design a Novel Methanol Utilization Pathway in E. Coli ». Metabolic Engineering 61 (1 septembre 2020): 315‑25. doi:10.1016/j.ymben.2020.07.005.
Morin, Manon, Brice Enjalbert, Delphine Ropers, Laurence Girbal, et Muriel Cocaign-Bousquet. « Genomewide Stabilization of MRNA during a “Feast-to-Famine” Growth Transition in Escherichia Coli ». Édité par Craig D. Ellermeier. MSphere 5, nᵒ 3 (20 mai 2020): e00276-20, /msphere/5/3/mSphere276-20.atom. doi:10.1128/mSphere.00276-20.
Wang, Zhi, Alexandra S. Tauzin, Elisabeth Laville, Pietro Tedesco, Fabien Létisse, Nicolas Terrapon, Pascale Lepercq, Myriam Mercade, et Gabrielle Potocki-Veronese. « Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria ». Édité par Vincent B. Young. MSphere 5, nᵒ 1 (8 janvier 2020): e00771-19, /msphere/5/1/mSphere771-19.atom. doi:10.1128/mSphere.00771-19.

2019

Öztürk, Sibel, İrem Demir, et Pınar Çalık. « Isolation of High‐Quality RNA from Pichia Pastoris ». Current Protocols in Protein Science 98, nᵒ 1 (décembre 2019). doi:10.1002/cpps.101.
Buvignier, Amaury, Matthieu Peyre-Lavigne, Orlane Robin, Mansour Bounouba, Cédric Patapy, Alexandra Bertron, et Etienne Paul. « Influence of Dissolved-Aluminum Concentration on Sulfur-Oxidizing Bacterial Activity in the Biodeterioration of Concrete ». Applied and Environmental Microbiology 85, nᵒ 15 (s. d.): e00302-19. doi:10.1128/AEM.00302-19.
Peiro, Camille, Pierre Millard, Alessandro de Simone, Edern Cahoreau, Lindsay Peyriga, Brice Enjalbert, et Stéphanie Heux. « Chemical and Metabolic Controls on Dihydroxyacetone Metabolism Lead to Suboptimal Growth of Escherichia Coli ». Applied and Environmental Microbiology 85, nᵒ 15 (1 août 2019). doi:10.1128/AEM.00768-19.
Lecomte, Sylvain, Florence Demay, Thu Ha Pham, Solenn Moulis, Théo Efstathiou, Frédéric Chalmel, et Farzad Pakdel. « Deciphering the Molecular Mechanisms Sustaining the Estrogenic Activity of the Two Major Dietary Compounds Zearalenone and Apigenin in ER-Positive Breast Cancer Cell Lines ». Nutrients 11, nᵒ 2 (février 2019): 237. doi:10.3390/nu11020237.
Pizzolato G, Kaminski H, Tosolini M, Franchini D-M, Pont F, Martins F, Valle C, Labourdette D, Cadot S, Quillet-Mary A, Poupot M, Laurent C, Ysebaert L, Meraviglia S, Dieli F, Merville P, Milpied P, Déchanet-Merville J, Fournié J-J. Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes. PNAS. 2019;116:11906–15. doi:10.1073/pnas.1818488116.
Marsaud N. Séquençage à haut débit - Outils et enjeux pour la santé humaine. Techniques de l’Ingénieur. 2019;:24. https://www.techniques-ingenieur.fr/base-documentaire/biomedical-pharma-th15/nanotechnologies-et-biotechnologies-pour-la-sante-42608210/sequencage-a-haut-debit-bio8205/.
Other publications ...

Instrument Access

For TBI members

Some machines are open for direct reservation.

Discover the range of offered services.

Before use a training is required.

Book online

Within GeT

Access to qPCR Biomark, ddPCR, Illumina sequencers and many other technologies and related skills...

We will answer you at get@genotoul.fr.

Contact

A multidisciplinary team will answer your requests.

  • photo ID
    Marie Ange Teste Platform and Administrative Manager- Biologist
    Biologist
  • photo ID
    Lidwine Trouilh Sequencing and Biochips Services (Agilent - Affymetrix - custom) Quality Manager
    Biologist
  • photo ID
    Nathalie Marsaud Sequencing and Biochips Services (Agilent - Affymetrix - custom)
    Biologist
  • photo ID
    Delphine Labourdette Bioinformatics and statistical data analysis (NGS and microarrays). Design of custom microarrays
    Bioinformatician
  • photo ID
    Etienne Rifa Targeted metagenomics analysis RNAseq, GenomeSeq
    Bioinformatician Biostatistician

Plateforme GeT-Biopuces
TBI - INSA - Bat 39
135, avenue de Rangueil
31077 Toulouse Cedex 4 - France

Locate us on a map

localisation on INSA campus