TBI platform for genomics and transcriptomics.
Sequencing and microarrays.

Technical Expertise

Certified ISO-9001 et NFX50-900

For academic and private research

From samples quality control to data analysis

taff with more than 15 years experience in the field


Microbiology referee within the regional GeT platform

Development of diagnostic and custom chips

Project accomodation



Non-disclosure agreements

Skill Transfert (Contact us) and
professional training sessions

About us

Created in 1999 and currently spearheaded by Marie-Ange Teste, the GeT-Biopuces core-facility is one of the first platform of the Génopôle Toulouse Midi Pyrénées (GenoToul).

Labellised IBISA and certifiée ISO 9001 since 2010, the GeT-Biopuces core-facility is dedicated in transcriptomics and genomics and offers service delivery and/or collaboration (R&D).

The Core Facilities and staff offer its expertise and advanced tools for sequencing, microarrays and analysis of bioinformatics and statistical data.

Thanks to the know-how of its multidisciplinary team, you are assisted along your project from its conception to the availability of raw or processed data.

Lots of academic (INRAE, CNRS, INSERM, IFREMER...) and private partners have trusted us to collaborate on fundamental or applied research projects in various fields such as microbiology, biotechnology, agri-food industry, health and the environment. Intellectual property issues and non-disclosure agreements can be discussed with the legal department of INSA.

The GeT-Biopuces platform is part of a cutting-edge multi-site core facility in Toulouse, named GeT for ‘Genome and Transcriptome’.

Thus we propose one of the most complete offers in France in the field of genomics and transcriptomics: DNA chips, small and long fragment high throughput sequencing technologies, ddPCR and single- cell

Services and Equipment

Why working with us ?

The platform offers the following services:

For any question, feel free to contact us, our staff will answer you a soon as possible.


Fayad, Nancy, Rita Barssoum, Nathalie Marsaud, Rayan Nasseredine, Nouha Abdelmalek, Souad Rouis, Marie Ange Teste, et al. 2023. “Complete Genome Sequences of Two Bacillus Thuringiensis Serovar Kurstaki Strains Isolated from Lebanon and Tunisia, Highly Toxic against Lepidopteran Larvae.” Microbiology Resource Announcements 12 (9): e00060-23. doi:10.1128/MRA.00060-23.
Guéraud, Françoise, Charline Buisson, Aurélie Promeyrat, Nathalie Naud, Edwin Fouché, Valérie Bézirard, Jacques Dupuy, et al. 2023. “Effects of Sodium Nitrite Reduction, Removal or Replacement on Cured and Cooked Meat for Microbiological Growth, Food Safety, Colon Ecosystem, and Colorectal Carcinogenesis in Fischer 344 Rats.” Npj Science of Food 7 (1): 53. doi:10.1038/s41538-023-00228-9.
Koreki, Axelle, Séverine Michel, Caroline Lebeaux, Lidwine Trouilh, and Christophe Délye. n.d. “Prevalence, Spatial Structure and Evolution of Resistance to Acetolactate-Synthase (ALS) Inhibitors and 2,4-D in the Major Weed Papaver Rhoeas (L.) Assessed Using a Massive, Country-Wide Sampling.” Pest Management Science n/a (n/a). Accessed November 20, 2023. doi:10.1002/ps.7791.
Verdier-Metz, Isabelle, Céline Delbès, Matthieu Bouchon, Etienne Rifa, Sébastien Theil, Frédérique Chaucheyras-Durand, Eric Chevaux, Lysiane Dunière, and Christophe Chassard. 2023. “Dietary Live Yeast Supplementation Influence on Cow’s Milk, Teat and Bedding Microbiota in a Grass-Diet Dairy System.” Microorganisms 11 (3): 673. doi:10.3390/microorganisms11030673.
Mervant, Loic, Marie Tremblay-Franco, Maiwenn Olier, Emilien Jamin, Jean-Francois Martin, Lidwine Trouilh, Charline Buisson, et al. « Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet-Santé Cohort and an in Vivo Intervention Study in Rats ». Molecular Nutrition & Food Research n/a, nᵒ n/a (s. d.): 2200432. doi:10.1002/mnfr.202200432.
Guéraud, Françoise, Charline Buisson, Aurélie Promeyrat, Nathalie Naud, Edwin Fouché, Valérie Bézirard, Jacques Dupuy, Pascale Plaisancié, Cécile Héliès-Toussaint, Lidwine Trouilh et al. « Reduction, Removal or Replacement of Sodium Nitrite in a Model of Cured and Cooked Meat: A Joint Evaluation of Consequences on Microbiological Issues in Food Safety, Colon Ecosystem and Colorectal Carcinogenesis ». bioRxiv, 25 mars 2023. doi:10.1101/2023.03.24.531666.
Defrel, Gilles, Nathalie Marsaud, Etienne Rifa, Frédéric Martins, et Fayza Daboussi. « Identification of Loci Enabling Stable and High-Level Heterologous Gene Expression ». Frontiers in Bioengineering and Biotechnology 9 (2021): 734902. doi:10.3389/fbioe.2021.734902.
Ropers, Delphine, Yohann Couté, Laëtitia Faure, Sabrina Ferré, Delphine Labourdette, Arieta Shabani, Lidwine Trouilh, et al. « Multiomics Study of Bacterial Growth Arrest in a Synthetic Biology Application ». ACS Synthetic Biology, 5 novembre 2021. doi:10.1021/acssynbio.1c00115.
Frétin, Marie, Amaury Gérard, Anne Ferlay, Bruno Martin, Solange Buchin, Sébastien Theil, Etienne Rifa, et al. 2022. “Integration of Multiomic Data to Characterize the Influence of Milk Fat Composition on Cantal-Type Cheese Microbiota.” Microorganisms 10 (2): 334. doi:
Verdier-Metz, Isabelle, Céline Delbès, Matthieu Bouchon, Philippe Pradel, Sébastien Theil, Etienne Rifa, Agnès Corbin, and Christophe Chassard. 2022. “Influence of Post-Milking Treatment on Microbial Diversity on the Cow Teat Skin and in Milk.” Dairy 3 (2): 262–76. doi:
Piqueras, Justine, Christophe Chassard, Cécile Callon, Etienne Rifa, Sébastien Theil, Annick Lebecque, et Céline Delbès. « Lactic Starter Dose Shapes S. Aureus and STEC O26:H11 Growth, and Bacterial Community Patterns in Raw Milk Uncooked Pressed Cheeses ». Microorganisms 9, nᵒ 5 (mai 2021): 1081. doi:10.3390/microorganisms9051081.
Marsaud N. Séquençage à haut débit - Outils et enjeux pour la santé humaine. Techniques de l’Ingénieur. 2019;:24.
Pizzolato G, Kaminski H, Tosolini M, Franchini D-M, Pont F, Martins F, Valle C, Labourdette D, Cadot S, Quillet-Mary A, Poupot M, Laurent C, Ysebaert L, Meraviglia S, Dieli F, Merville P, Milpied P, Déchanet-Merville J, Fournié J-J. Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes. PNAS. 2019;116:11906–15. doi:10.1073/pnas.1818488116.
Lamarre S, Frasse P, Zouine M, Labourdette D, Sainderichin E, Hu G, Le Berre-Anton V, Bouzayen M, Maza E. Optimization of an RNA-Seq Differential Gene Expression Analysis Depending on Biological Replicate Number and Library Size. Front Plant Sci. 2018;9. doi:10.3389/fpls.2018.00108.
Giraud S, Steichen C, Allain G, Couturier P, Labourdette D, Lamarre S, Ameteau V, Tillet S, Hannaert P, Thuillier R, Hauet T. Dynamic transcriptomic analysis of Ischemic Injury in a Porcine Pre-Clinical Model mimicking Donors Deceased after Circulatory Death. Sci Rep. 2018;8. doi:10.1038/s41598-018-24282-6.
Serif M, Dubois G, Finoux A-L, Teste M-A, Jallet D, Daboussi F. One-step generation of multiple gene knock-outs in the diatom Phaeodactylum tricornutum by DNA-free genome editing. Nature Communications. 2018;9:3924. doi:10.1038/s41467-018-06378-9.
Hoareau-Aveilla C, Quelen C, Congras A, Caillet N, Labourdette D, Dozier C, Brousset P, Lamant L, Meggetto F. MiR-497 suppresses cycle progression through an axis involving CDK6 in ALK-positive cells. Haematologica. 2018;:haematol.2018.195131. doi:10.3324/haematol.2018.195131.
Illikoud N, Klopp C, Roulet A, Bouchez O, Marsaud N, Jaffrès E, Zagorec M. One complete and three draft genome sequences of four Brochothrix thermosphacta strains, CD 337, TAP 175, BSAS1 3 and EBP 3070. Standards in Genomic Sciences. 2018;13:22. doi:10.1186/s40793-018-0333-z.
Debaugny RE, Sanchez A, Rech J, Labourdette D, Dorignac J, Geniet F, Palmeri J, Parmeggiani A, Boudsocq F, Anton Leberre V, Walter J, Bouet J. A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids. Mol Syst Biol. 2018;14. doi:10.15252/msb.20188516.

Acknowledgements & citations

Philippon, Timothé, Fatima-Zahra Ait-Itto, Alicia Monfort, Frédéric Barrière, et James A. Behan. « Fe(III) Oxide Microparticles Modulate Extracellular Electron Transfer in Anodic Biofilms Dominated by Bacteria of the Pelobacter Genus ». Bioelectrochemistry 151 (1 juin 2023): 108394. doi:10.1016/j.bioelechem.2023.108394.
Fournier, Elora, Jeremy Ratel, Sylvain Denis, Mathilde Leveque, Philippe Ruiz, Carine Mazal, Frederic Amiard, et al. « Exposure to Polyethylene Microplastics Alters Immature Gut Microbiome in an Infant in Vitro Gut Model ». Journal of Hazardous Materials 443 (5 février 2023): 130383. doi:10.1016/j.jhazmat.2022.130383.
Lepesant, Julie M J, Carole Iampietro, Eugenia Galeota, Benoit Augé, Marion Aguirrenbengoa, Clemèntine Mercé, Camille Chaubet, et al. « A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons ». Nucleic Acids Research 48, nᵒ 3 (20 février 2020): 1206‑24. doi:10.1093/nar/gkz114.
Guyet, Ulysse, Ngoc A. Nguyen, Hugo Doré, Julie Haguait, Justine Pittera, Maël Conan, Morgane Ratin, et al. « Synergic Effects of Temperature and Irradiance on the Physiology of the Marine Synechococcus Strain WH7803 ». Frontiers in Microbiology 11 (2020). doi:10.3389/fmicb.2020.01707.
O’Donohue, Michael, Laurence Fournaison, et Mélanie Delclos. « Division of Science for Food, Bioproducts and Waste TRANSFORM ». Report, INRAE, 2020. doi:10.15454/f6h4-fp08.
Fournier, Elora, Mathilde Leveque, Philippe Ruiz, Jeremy Ratel, Claude Durif, Sandrine Chalancon, Frederic Amiard, et al. « Microplastics: What Happens in the Human Digestive Tract? First Evidences in Adults Using in Vitro Gut Models ». Journal of Hazardous Materials 442 (15 janvier 2023): 130010. doi:10.1016/j.jhazmat.2022.130010.
Aboulela, Amr, Matthieu Peyre Lavigne, Tony Pons, Mansour Bounouba, Maud Schiettekatte, Pascale Lepercq, Myriam Mercade, Cédric Patapy, Samuel Meulenyzer, and Alexandra Bertron. 2022. “The Fate of Tetrathionate during the Development of a Biofilm in Biogenic Sulfuric Acid Attack on Different Cementitious Materials.” Science of The Total Environment 850 (December): 158031. doi:
Fournier, Elora, Sylvain Denis, Alessandra Dominicis, Tom Van de Wiele, Monique Alric, Muriel Mercier-Bonin, Lucie Etienne-Mesmin, and Stéphanie Blanquet-Diot. 2022. “A Child Is Not an Adult: Development of a New in Vitro Model of the Toddler Colon.” Applied Microbiology and Biotechnology 106 (21): 7315–36. doi:
Laguillaumie, Léa, Yan Rafrafi, Elisabeth Moya-Leclair, Delphine Delagnes, Simon Dubos, Mathieu Spérandio, Etienne Paul, and Claire Dumas. 2022. “Stability of Ex Situ Biological Methanation of H2/CO2 with a Mixed Microbial Culture in a Pilot Scale Bubble Column Reactor.” Bioresource Technology 354 (June): 127180. doi:
Laroute, Valérie, Catherine Beaufrand, Pedro Gomes, Sébastien Nouaille, Valérie Tondereau, Marie-Line Daveran-Mingot, Vassilia Theodorou, Hélène Eutamene, Muriel Mercier-Bonin, and Muriel Cocaign-Bousquet. 2022. “Lactococcus Lactis NCDO2118 Exerts Visceral Antinociceptive Properties in Rat via GABA Production in the Gastro-Intestinal Tract.” Edited by Gisela Storz. ELife 11 (June): e77100. doi:
Nguyen, Huong Le, Marie-Pierre Duviau, Sandrine Laguerre, Sébastien Nouaille, Muriel Cocaign-Bousquet, and Laurence Girbal. 2022. “Synergistic Regulation of Transcription and Translation in Escherichia Coli Revealed by Codirectional Increases in MRNA Concentration and Translation Efficiency.” Microbiology Spectrum 10 (1): e0204121. doi:
Pregnon, Guillaume, Nigel P. Minton, and Philippe Soucaille. 2022. “Genome Sequence of Eubacterium Limosum B2 and Evolution for Growth on a Mineral Medium with Methanol and CO2 as Sole Carbon Sources.” Microorganisms 10 (9): 1790. doi:
Paccoud, Romain, Céline Saint-Laurent, Enzo Piccolo, Mylène Tajan, Alizée Dortignac, Ophélie Pereira, Sophie Le Gonidec, et al. « SHP2 Drives Inflammation-Triggered Insulin Resistance by Reshaping Tissue Macrophage Populations ». Science Translational Medicine 13, nᵒ 591 (28 avril 2021). doi:10.1126/scitranslmed.abe2587. (remerciements
Millard, Pierre, Brice Enjalbert, Sandrine Uttenweiler-Joseph, Jean-Charles Portais, et Fabien Létisse. « Control and regulation of acetate overflow in Escherichia coli ». Édité par Michael Doebeli et Naama Barkai. eLife 10 (15 mars 2021): e63661. doi:10.7554/eLife.63661.
Arnould, Coline, Vincent Rocher, Anne-Laure Finoux, Thomas Clouaire, Kevin Li, Felix Zhou, Pierre Caron, et al. « Loop Extrusion as a Mechanism for Formation of DNA Damage Repair Foci ». Nature 590, nᵒ 7847 (février 2021): 660‑65. doi:10.1038/s41586-021-03193-z.
Courtot, Lilas, Elodie Bournique, Chrystelle Maric, Laure Guitton-Sert, Miguel Madrid-Mencía, Vera Pancaldi, Jean-Charles Cadoret, Jean-Sébastien Hoffmann, et Valérie Bergoglio. « Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing ». International Journal of Molecular Sciences 22, nᵒ 9 (janvier 2021): 4959. doi:10.3390/ijms22094959.
Pavlovic, Marion, Christelle Gross, Chahinaize Chili, Thomas Secher, et Emmanuel Treiner. « MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands ». Frontiers in Immunology 11 (8 septembre 2020): 2097. doi:10.3389/fimmu.2020.02097.
Tauzin, Alexandra S., Mariana Rangel Pereira, Liisa D. Van Vliet, Pierre-Yves Colin, Elisabeth Laville, Jeremy Esque, Sandrine Laguerre, et al. « Investigating Host-Microbiome Interactions by Droplet Based Microfluidics ». Microbiome 8, nᵒ 1 (décembre 2020): 141. doi:10.1186/s40168-020-00911-z.
Bertorello, Juliette, Julie Sesen, Julia Gilhodes, Solène Evrard, Monique Courtade-Saïdi, Meera Augustus, Emmanuelle Uro-Coste, et al. « Translation Reprogramming by EIF3 Linked to Glioblastoma Resistance ». NAR Cancer 2, nᵒ 3 (1 septembre 2020): zcaa020. doi:10.1093/narcan/zcaa020.
De Simone, A., C. M. Vicente, C. Peiro, L. Gales, F. Bellvert, B. Enjalbert, et S. Heux. « Mixing and Matching Methylotrophic Enzymes to Design a Novel Methanol Utilization Pathway in E. Coli ». Metabolic Engineering 61 (1 septembre 2020): 315‑25. doi:10.1016/j.ymben.2020.07.005.
Morin, Manon, Brice Enjalbert, Delphine Ropers, Laurence Girbal, et Muriel Cocaign-Bousquet. « Genomewide Stabilization of MRNA during a “Feast-to-Famine” Growth Transition in Escherichia Coli ». Édité par Craig D. Ellermeier. MSphere 5, nᵒ 3 (20 mai 2020): e00276-20, /msphere/5/3/mSphere276-20.atom. doi:10.1128/mSphere.00276-20.
Wang, Zhi, Alexandra S. Tauzin, Elisabeth Laville, Pietro Tedesco, Fabien Létisse, Nicolas Terrapon, Pascale Lepercq, Myriam Mercade, et Gabrielle Potocki-Veronese. « Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria ». Édité par Vincent B. Young. MSphere 5, nᵒ 1 (8 janvier 2020): e00771-19, /msphere/5/1/mSphere771-19.atom. doi:10.1128/mSphere.00771-19.
Other publications ...

Instrument Access

For TBI members

Some machines are open for direct reservation.

Discover the range of offered services.

Before use a training is required.

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Within GeT

Access to qPCR Biomark, ddPCR, Illumina sequencers and many other technologies and related skills...

We will answer you at


A multidisciplinary team will answer your requests.

  • photo ID
    Marie Ange Teste Platform and Administrative Manager- Biologist
  • photo ID
    Lidwine Trouilh Sequencing and Biochips Services (Agilent - Affymetrix - custom) Quality Manager
  • photo ID
    Nathalie Marsaud Sequencing and Biochips Services (Agilent - Affymetrix - custom)
  • photo ID
    Delphine Labourdette Bioinformatics and statistical data analysis (NGS and microarrays). Design of custom microarrays
  • photo ID
    Etienne Rifa Targeted metagenomics analysis RNAseq, GenomeSeq
    Bioinformatician Biostatistician
  • photo ID
    Jean-Luc Parrou R&D Développement de méthodes

Plateforme GeT-Biopuces
TBI - INSA - Bat 39
135, avenue de Rangueil
31077 Toulouse Cedex 4 - France

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localisation on INSA campus